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SUMMARY:YI-DGfI:Resistance against CART cell therapy in B-cell lymphoma
DTSTART;TZID=Europe/Berlin:20250728T170000
DTEND;TZID=Europe/Berlin:20250728T180000
DTSTAMP:20260516T131133Z
UID:a60a84acbe0b430abbd30f662683e989@www.bfb.uni-bonn.de
CREATED:20220124T085537Z
DESCRIPTION:YI-DGfI seminar series (seminars are open to everyone): \nRola
 nd Ullrich\, Department I of Internal Medicine\, University Hospital Colog
 ne\n\nTitle: Lymphoma-associated myeloid-monocytic (LAMM) cells mediate re
 sistance against CAR-T cell therapy in aggressive B-cell lymphoma\nCAR-T c
 ell therapy has improved the outcome of patients with relapsed or refracto
 ry (r/r) aggressive B cell lymphoma. However\, around 60% of patients do n
 ot derive durable benefit from CAR-T cell therapy. To elucidate hallmarks 
 associated with an immunosuppressive lymphoma microenvironment and CAR-T c
 ell resistance\, we applied high-dimensional analyses to pre- and post-CAR
 -T cell specimens. In patients with non-durable response\, we identified a
  prognostically relevant lymphoma-associated myelo-monocytic (LAMM) gene s
 ignature.
LAST-MODIFIED:20250906T030820Z
URL:https://www.bfb.uni-bonn.de/en/bfb-events/life-science-events-bonn/yi-
 dgfi-seminar-series
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